Synthesis and antifungal activity of diamidomethane linked oxazolyl/thiazolyl/imidazolyl isoxazoles

Nitrogen containing heterocyclic compounds have great utility in synthetic, medicinal and material chemistry. Oxazole, isoxazole, thiazole, imidazole their derivatives gained prominence as they constitute the structural features of many bioactive compounds. In fact, amide functionality represents a privileged scaffold biomolecules drugs. The combination two or more heterocycles linked by into one molecular framework would yield new chemical entities with enhanced pharmacological activities. Besides, development environmentally benign methods improved yields is highly desirable. our continued interest to synthesize variety heterocycles, we planned develop some isoxazoles oxazoles / thiazoles imidazoles adopting green methodologies study antifungal activity. results related these aspects will be presented.